Sr. Tech, Operations - Military Veterans

Job Description

Our Research and Development Division's San Diego, our company's Research Labs San Diego (Research Division San Diego) is committed to bringing life changing therapies to patients in need. With a patient-focused approach harnessing cutting-edge precision medicine, it is our mission to transform the landscape of inflammatory and auto immune diseases. The department of Immunology Discovery and Translational Sciences (leads and supports our company's pipeline programs encompassing early target discovery and validation, drug discovery, translational sciences, and precision medicine in collaboration with multi-disciplinary teams at our company, including bioinformatics, immunology discovery and chemical biology, antibody discovery, and clinical development.

Immunology Discovery and Translational Sciences is currently seeking a motivated, independent, versatile, and detail-oriented Sr. Scientist with a passion for improving patient lives to support internal discovery efforts at our Research Division in San Diego, CA. The Sr. Scientist will work in a matrixed environment with a focus on preclinical IND-enabling studies, and translational studies enabling indication prioritization and rationale combination therapies.

Main job duties include, but are not limited to:

• Working with team leaders to develop strategy and drive drug discovery, translational medicine, and precision medicine / diagnostics (Dx) discovery programs forward
• Conceptualize and perform cell-based functional assays (cell lines, primary cells, whole blood) to support target validation, antibody drug screening, mechanism of action studies, biomarker identification in the preclinical and IND-enabling space
• Developing and running cell-based assays to characterize drug target pathway activity or PD biomarkers in primary cells derived from patient samples
• Analyze, critically interpret data and share results to project teams as required
• Collaborating with bioinformatics and translational team members to generate datasets and identify biomarkers supporting translational medicine and Dx discovery
• Keep meticulous records of experiments performed and maintain lab notebook entries
• Representing IDTS in working groups and/or project teams
• Work collaborative with other scientists in the group in a highly matrixed lab environment

Qualifications:

Education:

• Bachelor's (with 7+years), Master's (with 5+ years) or Ph.D. in immunology, cell biology, or related biomedical science and relevant experience listed below

Required Experience and Skills:

• Strong cell culture skills including cell lines and primary cells
• Experience in multi-color flow cytometry to immunophenotype human cells (from blood or tissues), assess immune response or cell signaling pathways
• Experience developing ex-vivo cell-based assays to assess immune responses from human whole blood, PBMCs, and various immune cell subsets
• Proficiency in data analysis using Excel, Prism (GraphPad), FlowJo
• Experience with immunoassay platforms (e.g., ELISA, Meso Scale Discovery) to measure analytes in serum, plasma, supernatant or cell lysates is required
• Independent self-motivated life scientist who can generate scientific questions and design experiments to address them
• Scientific rigor and curiosity to address scientific questions and design experiments to test working hypothesis
• Excellent problem-solving and organizational skills
• Strong communication and interpersonal skills with an eagerness to work with and support colleagues across the organization in a matrixed environment

Preferred Experience and Skills:

• Understanding of the drug discovery process with industry experience
• Experience in spectral flow cytometry
• Experience with molecular/ cell biology techniques such as CRISPR, RT-PCR, cell transfection, cell line generation
• Experience in NGS platforms
• Understanding of immune diseases, including current research and drugs in development
• Experience in developing and running transcriptomics experiments (bulk and single cell RNAseq)
• Background in biomarker discovery and development

#EligibleforERP

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively.

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U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote".

The Company is required to provide a reasonable estimate of the salary range for this job in certain states and cities within the United States. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate's relevant skills, experience, and education.

Expected US salary range:
$114,700.00 - $180,500.00

Available benefits include bonus eligibility, long term incentive if applicable, health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and sick days. A summary of benefits is listed here .

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:
Regular

Relocation:
Domestic

VISA Sponsorship:
No

Travel Requirements:
10%

Flexible Work Arrangements:
Not Applicable

Shift:
1st - Day

Valid Driving License:
No

Hazardous Material(s):
YES

Job Posting End Date:
02/11/2025
*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.