Director, Engineering- Technical Product Leader - Military Veterans

Job Description

Scientist - In Vitro Neuroimmunology- Boston, MA

Our company's Neuroimmunology team in Boston, MA is seeking an independent and motivated scientist with a background in cell biology, immunology, and/or neuroscience to join us in validating and advancing novel neuroimmune targets for CNS diseases. As a Scientist, you will apply your knowledge and skillsets to establish assay systems and deliver datasets that will impact pipeline programs. Working in this lab-based position, your primary role will be to execute in vitro experiments including designing, establishing, and characterizing cell-based model systems, especially induced pluripotent stem cell (IPSC) models, and performing analysis in support of established and emerging therapeutic discovery programs. Successful candidates will be able to work independently and will be expected to proactively collaborate with colleagues across disciplines. The candidate will be an active participant in the positive and critical scientific dialogue that supports our mission of discovering novel immune-based therapies for CNS diseases.

The responsibilities of the Neuroimmunology team member include:

• Assist in developing, executing, and troubleshooting new cell-based assays, protocols, and analysis methods.
• Design and execute experiments, interpret data, and communicate results and findings clearly and concisely to teams and stakeholders
• Support the isolation/characterization of tissues, whole blood, PBMCs and iPSC-derived cell populations using immunocytochemistry, DNA/RNA isolation, PCR, NanosString, RNA-seq and other molecular biology techniques.
• Collaborate across functional areas
• Excellent oral and written communication of data in a clear and concise manner to the appropriate teams and stakeholders.
• Monitor and review published work to guide internal research.

EDUCATION:

• BS degree in molecular and cell biology or related disciplines such as immunology or biological engineering with 2+ years of wet lab experience in academia or industry OR MS and 0+ years of experience.

REQUIRED SKILLS:

• Demonstrated ability to thrive independently and in a team environment.
• Extensive experience with iPSC cell culture including constructing increasingly complex in vitro models
• Design, develop and execute novel in-vitro assays across multiple platforms for compound screening
• Application of standard laboratory cell culture procedures including DNA transfection, viral delivery and immunocytochemistry
• Independently able to perform tissue and cellular protein/RNA preps, quantitative PCR, western blots, and ELISAs
• Strong data analysis skills including a knowledge of statistics
• Excellent oral and written communication skills, including preparation of study reports, presentations and able to contribute manuscripts for publication in peer reviewed journals.
• This position requires 90% of time in the lab.

PREFERRED

• Primary neuronal/astrocyte culture experience
• Application of high-content imaging to cell-based assays
• Experience culturing immune cell lines, primary murine microglia and iPSC-derived microglia
• Experience with multiple therapeutic modalities (small molecule, antibody, peptide, siRNA).
• Experience in neuroscience and pharmaceutical research; Alzheimer's, Parkinson's and ALS disease experience preferred
• Record of innovative thinking to champion new ideas and solve problems reflected by contributions to peer reviewed publication.

#eligibleforERP

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively.

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U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote".

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:
Regular

Relocation:
No relocation

VISA Sponsorship:
No

Travel Requirements:
No Travel Required

Flexible Work Arrangements:
Not Applicable

Shift:
Not Indicated

Valid Driving License:
No

Hazardous Material(s):
OEB4

Job Posting End Date:
12/20/2024
*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.