Senior Principal Scientist, Cellular Pharmacology and Lead Discovery - Military Veterans

Job Description

The Future Talent Program features internships that last 12 weeks and will include one or more projects. These opportunities in our company's Research Labs can provide you with great development and a chance to see if we are the right company for your long-term goals.

Translational Molecular Biomarkers (TMB) is responsible for the development and execution of clinical biomarker assays across all therapeutic areas and all phases of clinical development. TMB laboratories leverage a diverse array of technologies to develop biomarker assays to help confirm engagement of therapeutic targets and understand mechanisms drug action and patient response.

The Molecular Pathology team within the TMB organization is seeking a highly motivated candidate to join us to work with our teams on tissue-based biomarker assays that will help guide therapeutic programs.

Qualifications
Education Minimum Requirement:

• MS or PhD (currently enrolled) in a life sciences discipline (Biochemistry, Immunology, Molecular Pathology, Cell Biology, etc.).

Required Experience and Skills:

• Excellent communication skills, both verbal and written.


• Self-motivated and eager to learn and evaluate new technologies.


• Hands-on experience in histopathology-based assays (IHC, mIF, ISH) and digital image analysis.


• Proficient in working with microscopy - brightfield and fluorescent high resolution/large images and file formats.


• Familiar with tissue morphology.


• Skilled in using statistical software packages (e.g., Prism, SPSS).

Qualities:

• Adaptable to changing needs and priorities


• Cooperative and supportive of team goals


• Able to work well with others and contribute to a positive work environment


• Creative and willing to explore new ideas and approaches

Responsibilities:

• We are seeking a highly motivated intern currently enrolled in an MS or PhD program to join our Translational Molecular Biomarkers (TMB) - Molecular Pathology team. The candidate will work under the guidance of a TMB Scientist. The ideal candidate must have excellent written and verbal communication skills to clearly communicate scientific objectives and interpret data. Additionally, the candidate should have a strong interest in Translational Sciences, along with a willingness to learn histopathology-based assay development and digital image analysis. This individual will play a role in assisting with the development of histopathology-based assays and exploratory biomarker analysis supporting clinical trials.

Key Responsibilities

• Perform automated IHC/mIF/ISH assays to generate images for digital pathology analysis.


• Utilize various commercial image analysis software packages (e.g., Visiopharm, HALO) as well as non-commercial software packages such as QuPath to conduct digital image analysis.


• Develop software algorithms (using AI, if necessary) to detect specific sub-cellular staining (e.g., cytoplasm vs. membrane) and tumor/stroma segmentation methods.


• Identify a suitable digital image platform for accurate analysis of IHC, mIF, and ISH staining.


• Utilize the optimized software algorithms to perform digital image analysis of exploratory biomarker assays.

Under New York City, Colorado State, Washington State, and California State law, the Company is required to provide a reasonable estimate of the salary range for this job. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate's relevant skills, experience, and education.

Expected salary range:

$39,600.00-$105,500.00

FTP2025

MRL2025

Employees working in roles that the Company determines require routine collaboration with external stakeholders, such as customer-facing commercial, or research-based roles, will be expected to comply not only with Company policy but also with policies established by such external stakeholders (for example, a requirement to be vaccinated against COVID-19 in order to access a facility or meet with stakeholders). Please understand that, as permitted by applicable law, if you have not been vaccinated against COVID-19 and an essential function of your job is to call on external stakeholders who require vaccination to enter their premises or engage in face-to-face meetings, then your employment may pose an undue burden to business operations, in which case you may not be offered employment, or your employment could be terminated. Please also note that, where permitted by applicable law, the Company reserves the right to require COVID-19 vaccinations for positions, such as in Global Employee Health, where the Company determines in its discretion that the nature of the role presents an increased risk of disease transmission.

Current Employees apply HERE

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We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

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U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, generally Tuesday, Wednesday and either Monday or Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence. This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote".

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Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:
Intern/Co-op (Fixed Term)

Relocation:
No relocation

VISA Sponsorship:
No

Travel Requirements:
No Travel Required

Flexible Work Arrangements:
Not Applicable

Shift:
1st - Day

Valid Driving License:
No

Hazardous Material(s):
YES

Job Posting End Date:
10/28/2024
*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.