Senior Principal Scientist, Computational Biology - Military Veterans

Job Description

The Precision Genetics group within the Data and Genome Sciences Department is recruiting a Sr. Director to lead the Statistical Genetics team based in Cambridge, MA. We are seeking an experienced Statistical Geneticist with a proven track-record of delivering novel targets/biomarkers from analyses of Biobank scale human genetics data.

You will lead a team of statistical geneticists to create bespoke strategies for specific complex diseases across multiple therapeutic areas. As such you will leverage our Company data assets along with public data resources to identify disease mechanisms with a goal to deliver novel targets with human genetics support.

You will serve as a strategic partner to our discovery and clinical colleagues and will shape the genetics strategies across our company's drug discovery portfolio. You will also assume a hands-on leadership role, implementing rigorous data analysis practices, aligning resources based on scientific priorities, and mentoring and developing team members. You will operate in a highly collaborative environment, partnering with peers across multiple locations and in the broader scientific community.

In this exciting role, you will:

• Manage, mentor and hire outstanding team members responsible for creating bespoke target discovery and precision medicine strategies across therapeutic areas
• Design and implement a cloud-scale discovery engine based on human genetics data which can be adapted quickly to understand disease mechanism, patient sub-populations and discover novel drug targets
• Conduct fit-for-purpose GWAS/RVAS from Biobank scale data (UKBB, FinnGen and others) and meta analyze summary statistics
• Perform post-GWAS analysis (Fine mapping, colocalization, functional enrichment, Mendelian Randomization, TWAS, PrediXcan, LDSC, V2G etc.)
• Integrate GWAS with RNA-seq, ATAC-seq, ChIP-seq, QTLs etc. to generate multiple layers of evidence to prioritize candidate targets and understand disease mechanism.
• Be at the cutting edge of emerging methods in statistical genetics
• Tackle complex projects, anticipate, and overcome challenges, and forecast timelines for deliverables to support pipeline objectives
• Collaborate with wet-lab biologists and disease area experts to validate disease mechanisms and patient sub-populations
• Communicate results to project teams, our company's scientific community, and the external scientific community through internal documents, presentations, and publications in leading journals
• Coding experience in R and/or Python and other statistical genetics software

Required Experience and Skills:

• Ph.D . in s tatistical genetics, genetic epidemiology, or related field, plus a minimum of 10 years post-PhD research experience
• A solid track record of 5+ years leading high-performing statistical genetics teams.
• Strong foundational knowledge of statistical/population genetics (GWAS, QTL mapping, heritability estimation, etc.)
• Demonstrated experience applying post-GWAS analyses to understand disease mechanisms (fine mapping, colocalization, functional enrichment, etc.)
• Demonstrated experience in generating SNP imputations models for endophenotypes (PrediXcan etc)
• Demonstrated expertise in using human genetics to deliver novel drug targets (Mendelian Randomization, TWAS)
• Ability to code in R/Python and establish best practices for reproducible data analyses.
• Strong ability to work and influence in complex matrixed organizations.
• Excellent oral and written communication skills

Preferred Experience and Skills:

• Experience in any if Neuroscience, Cardiovascular and Metabolic diseases, Immunology and/or other complex diseases
• Experience in integrating single-cell transcriptomics with human genetics for advancing insights of disease mechanisms

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

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Employees working in roles that the Company determines require routine collaboration with external stakeholders, such as customer-facing commercial, or research-based roles, will be expected to comply not only with Company policy but also with policies established by such external stakeholders (for example, a requirement to be vaccinated against COVID-19 in order to access a facility or meet with stakeholders). Please understand that, as permitted by applicable law, if you have not been vaccinated against COVID-19 and an essential function of your job is to call on external stakeholders who require vaccination to enter their premises or engage in face-to-face meetings, then your employment may pose an undue burden to business operations, in which case you may not be offered employment, or your employment could be terminated. Please also note that, where permitted by applicable law, the Company reserves the right to require COVID-19 vaccinations for positions, such as in Global Employee Health, where the Company determines in its discretion that the nature of the role presents an increased risk of disease transmission.

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Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, generally Tuesday, Wednesday and either Monday or Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence. This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote".

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Employee Status:
Regular

Relocation:
Domestic

VISA Sponsorship:
Yes

Travel Requirements:
10%

Flexible Work Arrangements:
Hybrid

Shift:
1st - Day

Valid Driving License:
No

Hazardous Material(s):
n/a

Required Skills:
Biomarkers, Building High Performance Team, Data Analysis, Data Science, Genetic Epidemiology, Human Genetics, Machine Learning, Population Genetics, Scientific Modeling, Statistical Genetics

Preferred Skills:

Job Posting End Date:
10/28/2024
*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.