Researcher 5 - Military Veterans

Focusing on structural and functional studies of virus and host interactions, the Hafenstein lab is fully outfitted for mammalian cell culture, large-scale virus, and protein expression and purification, as well as biochemical analysis. Researchers enjoy access to a state-of-the-art in-house Cryo-EM facility featuring a Titan Krios microscope equipped with an energy filter and K3 Direct electron detector. A planned expansion includes the acquisition of a second Titan Krios with Selectris and Falcon 4i detector, an Arctis FIB/SEM, and all ancillary equipment for tomography. The Hormel Institute also houses an equipment core including fluorescent microscopes as well as analytical ultracentrifugation, ITC and BIACORE instruments, along with shared common use high speed centrifuges and a range of other high-end microscopes. The core facilities are further supported by dedicated facility managers responsible for training, support, and usage of equipment.

Focus of Job Responsibilities

Conduct and lead scientific research efforts in the study of how virus interact with the host.
Collaborate with researchers to provide a structural basis for understanding the mechanisms of entry, assembly, maturation, and how viruses are recognized by host immune system.
Use cryo-electron microscopy (Cryo-EM) and cryo-electron tomography (cryo-ET). Although experience is preferred a strong candidate who requires training in Cryo-EM single particle and tomography will be considered.
Lead the development of protocols on the newly acquired Arctis and tomography workflow.
Lead the development of sample preparation and presentation for in situ experiments using the Arctis.
Conduct biochemical experiments.
Analyze research methods and data.
Write research reports and give scientific presentations.
Maintain a safe, clean, and functional laboratory.
Assist with training of new or junior researchers and Cryo-EM/ET workshops for the community.

Ongoing Research â" 70%
Design and implementation of hypothesis-driven research projects.

Analysis & Review â" 15%
Analysis and review of generated data and reviewing previously reported scientific literature.

Scientific Writing â" 15%
Including reporting research findings in manuscripts for publication in peer-reviewed biomedical journals and grant writing.
Generation of figures for manuscripts and grants proposals.

The Research and Innovation Office (RIO) and The Hormel Institute endorses a âœwork with flexibilityâ approach that offers a welcoming and flexible work environment where everyone is inspired to do their best. Work location options include working fully remote, partially remote, or entirely in the office and are based on the work of the position. Some on-site work may be necessary for certain positions, even those designated as fully remote. Because we are a land-grant institution that serves the state, the University will continue to- in most cases- expect employees to live in Minnesota.

This position has been designated as eligible for Flexible Work Profile One.
Flexible Work Profile One is expected to work primarily on-site. Your office will be located at The Hormel Institute in Austin, MN. The Hormel Institute management retains the right to modify flexible work arrangement agreements on a temporary or permanent basis for any reason at any time.

Required Qualifications
Advanced degree with one or more years in research training.

Preferred Qualifications
Ph.D., DDS, DVM, JD, MD or equivalent.
Demonstrable experience in basic biochemistry and molecular biology techniques is required.
Candidates with experience in structural biology, particularly interpretation of intermediate resolution EM or X-ray maps and model building are strongly encouraged to apply.