Postdoctoral Fellow - Moses Lab | Cold Spring Harbor Laboratory - Military Veterans

Position Description

The Moses Laboratory, established in 2020 at Cold Spring Harbor Laboratory (CSHL), is the first chemistry focused laboratory at CSHL, led by the renowned Prof. John Moses. Known for advancements in click chemistry reaction development and application, the Moses Laboratory employs cutting-edge click reactions such as Sulfur Fluoride Exchange (SuFEx) and Phosphorus Fluoride Exchange (PFEx) to pioneer novel anticancer therapies. The Moses Laboratorys primary objective is to identify functional molecules efficiently, working in collaboration with a network of biologists at CSHL to evaluate hit compound potencies and thoroughly probe underlying mechanisms of action. These studies often involve the synthesis of bespoke chemical probes and conducting protein pulldown experiments to identify therapeutic targets. By integrating chemistry and biology, the Moses Laboratory aims to accelerate the development of novel therapies for aggressive cancers, including pancreatic ductal adenocarcinoma and triple-negative breast cancer. We are seeking a postdoctoral researcher with a background in biology to complement and support the ongoing chemistry work in our laboratory. The ideal candidate will possess significant expertise in protein target identification and purification, coupled with proficiency in executing cell-based assays such as cytotoxicity evaluations in both 2D and 3D cancer models. Experience in generating knockout cell lines to validate suspected mechanisms of action is highly desirable. The successful candidate will work collaboratively with other distinguished members of the CSHL community to advance our cutting-edge research programs.

Position Requirements

Education : Candidates must hold a PhD degree. Skills: Experience evaluating small molecules for cytotoxicity in human cell culture (e.g., determining IC50 and AUC values) Experience conducting biophysical assays to probe underlying mechanisms of action (e.g., receptor engagement and enzyme inhibition assays). Proficiency in purifying proteins, conducting protein target identification, and associated pulldown experiments. Ability to generate knockout cells and auxin-inducible cell lines. Proficiency with qPCR and western blot techniques. Experience with analyzing data using relevant software (e.g., Prism). Experience: Live cell imaging. Flow cytometry. Generation of recombinant proteins. Ability to perform Tier 1 ADME screens/use relevant kits (Metabolism kits, Caco-2, CYP inhibition/induction). Xenograft mice models.

Supplemental Information

How to Apply: If you are eager to contribute to groundbreaking research, we encourage you to apply for this exciting opportunity. Please submit an online application here: Postdoctoral Fellow- Moses Lab Position 01138. Interested candidates should also submit a CV, a short description of how our research interests overlap, and contact information for two references to: moses@cshl.edu. We look forward to reviewing your application. Environment Cold Spring Harbor Laboratory is a world-renowned biomedical research institution in New York. It has shaped contemporary biomedical research and is the home of eight Nobel Prize laureates. Cold Spring Harbor Laboratory provides a highly dynamic and interactive research environment and also a unique opportunity of timely exposure to advances in various biomedical research fields and of interaction with a broad range of researchers from all over the world through its renowned Meetings and Courses program. We believe that science is for everyone. We have had researchers with a variety of backgrounds and believe in the importance of diversity, equity, and inclusion. Compensation & Benefits Our employees are compensated in many ways for their contributions to our mission, including competitive pay, exceptional health benefits, retirement plans, paid time off, and a range of recognition and wellness programs. Visit our CSHL Benefits , Postdoctoral Landing & Postdoctoral Fellow Stipend Schedule (Download PDF reader) (Download PDF reader) (Download PDF reader) sites to learn more. The salary for this role is $72,800.00 per annum. The salary range or hourly rate listed is a good faith determination of potential base compensation that may be offered to a successful applicant for this position at the time of this job advertisement and may be modified in the future. When determining a base salary and/or rate, several factors may be considered as applicable (e.g., years of relevant experience, education, credentials, and internal equity). We strongly recommend to be fully vaccinated for COVID-19 however; it is not a requirement for employment. CSHL is an EO/AA Employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability or protected veteran status. VEVRAA Federal Contractor