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Path 1 Kawader: Protein Biochemist | New York University - Military Veterans

at HERC - Metro New York & Southern Connecticut

RESEARCH PROJECT TITLE: Bioluminescence and the Determination of the Color Emission Mechanism FACULTY NAME & TITLE: WAEL RABEH, PH.D., ASSISTANT PROFESSOR OF PRACTICE OF CHEMISTRY RESEARCH PROJECT DESCRIPTION Bioluminescence is found in various living organisms including bacteria, fireflies, beetles, marine organisms, and others. Luminous organisms produce light from an enzymatic reaction that involves the enzyme luciferase and its substrates luciferin and ATP in their ground state to produce a high-energy product in excited state that decays back to the ground state and release energy as a photon of visible light. Luciferase assays are used in biological and medical research, which currently represents the main analytical platform in the in vivo imaging, cell proliferation, and protein folding and secretion. Investigating the kinetic and emission color mechanisms of the luciferase reaction will improve and diverse some of the existing assays and develop new applications. In this project, we would like to study the structural and mechanistic properties of two different enzymes that produce red and green luminescence. The substrates of the two enzymes are identical, however, different luminescence color is produced as a result of different enzymes' structures. To characterize the color difference between the two enzymes, we will express and purify the protein in bacterial expression system. The protein will be characterized using different spectral techniques, X-ray crystallography, and enzyme kinetics. RESPONSIBILITIES OF THE POSITION Molecular Biology: DNA cloning and manipulation. Express and purify proteins using E.coli expression system. Protein X-ray crystallography and three-dimensional structural determination. Enzyme kinetics ESSENTIAL QUALIFICATIONS: Biology or Chemistry degree PREFERRED EXPERIENCE / SKILLS: Prior experience in wet lab with good technical and safety skills. 1. Statement of interest in the position 2. Transcript of degree(s) 3. CV 4. Two letters of recommendation UAE nationals are encouraged to apply This position is under the NYUAD Kawader program, for details regarding the program, open dates, specific program requirements, and FAQ's please refer to our NYUAD Kawader webpage: https://nyuad.nyu.edu/en/about/careers/postdoctoral-and-research/kawader-research-assistantship-program.html For further information or questions regarding the position/program please contact nyuad.kawader@nyu.edu (due to the high volume of emails received, please allow 5 working days for a response) For people in the EU, click here for information on your privacy rights under GDPR: www.nyu.edu/it/gdpr NYU is an equal opportunity employer committed to equity, diversity, and social inclusion.

Abu Dhabi, Abu Dhabi

HERC - Metro New York & Southern Connecticut

The Higher Education Recruitment Consortium (HERC) is a national nonprofit network of higher education and affiliated employers, committed to institutional collaboration, creating diverse workplaces, and assisting dual career couples. Searching for a job in higher ed? Our job board hosts over 30,000 faculty and staff jobs at workplaces that value diversity, equity, and inclusion. Set up your job seeker account today at: http://www.hercjobs.org For our member institutions, we offer recruitment and retention resources, vibrant regional networks, and a new online community of practice, HERConnect. All of our resources can help you advance inclusive excellence at your institution.

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